Who portrays Mrs. Wheeler Wheeler? Which actor takes on the role of Karen Wheeler in the series? Who is the performer behind Karen Wheeler? Mrs. Wheeler is portrayed by which actress? What actress acts as the character of Karen Wheeler on the series? Who is the talent personifying Karen Wheeler's character to life? What performer takes on the role of Karen Mrs. Wheeler in the television show? Who acts Karen Wheeler? Whom is the talented individual enacting Karen the mother on the show? What actress incarnates the character of Karen Wheeler to the screen?